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Dan C. Martin, MD
UT Medical Group,
Inc.

University of Tennessee Health Science Center (UTHSC)
Academic Office

Daniel Clyde Martin, M.D.
UT Medical Group,
Inc.
Infertility and Gynecology
Reproductive Surgery
Germantown Office Building
7945 Wolf River Boulevard
Suite 320
Germantown, Tennessee
TN 38138-1733
(901) 347-8331
(901) 347-8188 fax
Directions to Office
Updated information is
at
UTMG 2006
Click for information
on:
Glenn Ann Martin, Ph.D.
Clinical
Psychologist
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CLOMIPHENE INFORMATION
See the bottom of this page for
information on letrozole



I. Clomiphene citrate, Clomid and Serophene are the same medicine.
Downloadable PDF
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These are usually
started day 3 to 5 of a cycle with a pregnancy test negative or
with the temperature down. |
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An examination is done
before starting clomiphene when there is pain, fullness, or pelvic discomfort
to check for a cyst. This exam can also be done routinely when there are no
problems as some cysts cause no problems. If there is a cyst, clomiphene is
stopped until the cyst goes away. |
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Clomiphene can interfere
with the mucus and sperm interaction. |
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Urinary
ovulation tests can cross react with clomiphene. Start testing 3
days after finishing clomiphene |
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All ovulation tests give
similar monitoring information when they work. However, vaginal mucus
and urinary ovulation testing give better timing information for planning sex. |
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II. Management
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85% of all pregnancies
occur in the first three ovulatory cycles.1,2 |
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If not pregnant in
three to six ovulatory cycles, more intensive techniques such as Pergonal,
artificial insemination, or in vitro fertilization can be considered. |
III. Side effects include:
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Mood
swings and hot flashes are common. |
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Patients
seeing Dr. Martin have had one set of
quadruplets, five sets of triplets, and uncounted number of twins on clomiphene in 30
years. |
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Ovarian cysts may cause
pressure, pain or fullness; you should be checked if any one of these occur.
On rare occasion, these can require hospitalization. |
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There is a possibility of birth defects if
clomiphene is taken while or shortly before you are pregnant. This can happen if you are
pregnant but having breakthrough bleeding which you think is your period. Use
pregnancy tests if you have any doubt. Symptoms of pregnancy include breast
tenderness, nausea and pelvic fullness. |
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IV. Clomiphene does
not always help. It may:
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Interfere with sperm and
mucus interaction, |
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Decrease the growth of
the uterine lining and decrease success. Sonograms may be useful in
determining this. |
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Interfere with
hormones that control ovulation, conception, and growth. |
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Decrease
fertility with inseminations for male problems. |
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IX. Estimated pregnancy rates:
Clomiphene %
Ovulating % Of ovulating % Of all
dose
patients pregnant patients pregnant
50 44%
54% 24%
100
34% 50% 17%
150
28% 42% 12%
200
22% 68% 15%
250
20% 67% 14%
250 + hCG
10% 43% 5%
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Click here for downloadable Clomiphene PDF with additional information
Additional information is at
http://www.fertilitylifelines.com/initialtreatments/clomiphenecitrate/how.jsp
Letrozole isan aromatase inhibitor that works similar to clomiphene.
Information is at
http://www.ivf.com/clom.html 


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