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Dan C. Martin, MD
UT Medical Group, Inc.

University of Tennessee Health Science Center (UTHSC)
Academic Office

Daniel Clyde Martin, M.D.
UT Medical Group, Inc.
Infertility and Gynecology
Reproductive Surgery
Germantown Office Building
7945 Wolf River Boulevard
Suite 320
Germantown, Tennessee
TN 38138-1733

(901) 347-8331
(901) 347-8188 fax
Directions to Office

Updated information is at
UTMG 2006

Click for information on:
Glenn Ann Martin, Ph.D.
Clinical Psychologist

 

CLOMIPHENE INFORMATION

See the bottom of this page for information on letrozole

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         I.  Clomiphene citrate, Clomid and Serophene are the same medicine.
              Downloadable PDF

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These are usually started day 3 to 5 of a cycle with a pregnancy test negative or with the temperature down.

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An examination is done before starting clomiphene when there is pain, fullness, or pelvic discomfort to check for a cyst.  This exam can also be done routinely when there are no problems as some cysts cause no problems.  If there is a cyst, clomiphene is stopped until the cyst goes away.

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Clomiphene can interfere with the mucus and sperm interaction.

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Urinary ovulation tests can cross react with clomiphene.  Start testing 3 days after finishing clomiphene

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All ovulation tests give similar monitoring information when they work.  However, vaginal mucus and urinary ovulation testing give better timing information for planning sex.

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         II.  Management

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85% of all pregnancies occur in the first three ovulatory cycles.1,2

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 If not pregnant in three to six ovulatory cycles, more intensive techniques such as Pergonal, artificial insemination, or in vitro fertilization can be considered.

         III.  Side effects include:

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Mood swings and hot flashes are common.

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 Patients seeing Dr. Martin have had one set of quadruplets, five sets of triplets, and uncounted number of twins on clomiphene in 30 years.

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Ovarian cysts may cause pressure, pain or fullness; you should be checked if any one of these occur.  On rare occasion, these can require hospitalization.

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There is a possibility of birth defects if clomiphene is taken while or shortly before you are pregnant.  This can happen if you are pregnant but having breakthrough bleeding which you think is your period.  Use pregnancy tests if you have any doubt.  Symptoms of pregnancy include breast tenderness, nausea and pelvic fullness. 

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         IV.  Clomiphene does not always help.  It may:

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Interfere with sperm and mucus interaction,

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Decrease the growth of the uterine lining and decrease success.  Sonograms may be useful in determining this.

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Interfere with hormones that control ovulation, conception, and growth.

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Decrease fertility with inseminations for male problems.

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IX.    Estimated pregnancy rates:

     Clomiphene   % Ovulating   % Of ovulating           % Of all
           dose    
                     patients pregnant     patients pregnant

                50               44%              54%                     24%       
              100               34%              50%                      17%
              150               28%              42%                      12%
              200              22%               68%                      15%
              250              20%               67%                      14%
        
250 + hCG        10%               43%                        5%

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Click here for downloadable Clomiphene PDF with additional information

Additional information is at

http://www.fertilitylifelines.com/initialtreatments/clomiphenecitrate/how.jsp

 

 

Letrozole isan aromatase inhibitor that works similar to clomiphene.  Information is at

http://www.ivf.com/clom.html

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