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Dan C. Martin, MD
Daniel Clyde Martin, M.D. (901) 347-8331 Updated information is
at Click for information
on: |
FSH Testing
for Ovarian Aging
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Day 1 is the first day of bleeding | |
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Blood test on day 3 | |
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Clomiphene 100 mg (two 50 mg pills) day 5 to 9 by mouth | |
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Blood test on day 10 |
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Healthy day 3 and day 10 FSH levels are less than 10. | |
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Values of 10 to 18 are intermediate and are sometimes associated with lower fertility and higher miscarriage rates. | |
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Pregnancies are rare and miscarriages increase with high FSH values more than 18. The clinical name for this is diminished ovarian reserve (DOR). The miscarriage rate has been 57% at age 35 and 90% at age 40 with DOR. DOR is often treated with donor eggs. However, hormonal treatment with estrogen and progesterone has lowered the miscarriage rates to 30% and 50% in one study. Successful pregnancies have occurred with values as high as 143 using hormonal treatment in one study. The highest value in my practice has been 22. | |
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Live births have generally occurred when the day 3 FSH is less than 14, the estradiol less than 81, and the age less than 43 years. |
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Buyalos RP; Daneshmand S; and Brzechffa PR. Basal estradiol and follicle-stimulating hormone predict fecundity in women of advanced reproductive age undergoing ovulation induction therapy. Fertil Steril 68:272-277, 1997 | |
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Check JH, Check ML, Katsoff D. Three pregnancies despite elevated serum FSH and age. Human Reprod 2000 | |
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Corson SL. The simple screen can predict ART failure. Ob/Gyn Management, pages 30-34, October, 1998. | |
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Levi AJ; Raynault MF; Bergh PA; Drews M R; Miller BT; Scott RT. Reproductive outcome in patients with diminished ovarian reserve. Fertil Steril. 76: 666-669, 2001. | |
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Trout SW; Seifer DB. Do women with unexplained recurrent pregnancy loss have higher day 3 serum FSH and estradiol values? Fertil Steril 74: 335-337, 2000. |
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